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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
College of Biological Sciences
Medical School
Department of Genetics, Cell Biology, and Development

PI: Laura P.W. Ranum

Genetic Mapping of a Novel Familial Form of ALS

Using known differences in DNA, called single nucleotide polymorphisms, these researchers identified all of the genomic regions that are the same between five affected members of a family that has a unique form of amyotrophic lateral sclerosis (ALS). This method allowed the researchers to identify all of the regions where the mutation that causes this typical autosomal dominant ALS disorder could be located. They identified three regions, spanning 23 million base pairs, which were most likely to harbor the gene and they are now using high-throughput sequencing to identify the mutation. By discovering a new mutation that causes a form of ALS that is similar to the more common sporadic ALS, the researchers hope to provide insight into the pathogenic mechanisms of this devastating disorder. 

Group Members

Celine Kang, Graduate Student
Katherine Dick Krueger, Graduate Student