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Research Abstracts Online
January 2010 - March 2011

Main TOC

University of Minnesota Duluth
Medical School Duluth
Department of Biochemistry and Molecular Biology

PI: Jean F. Regal

Differential Allergen Sensitivity in Asthma of Young and Adult Animals

The objective of this research is to determine if young and adult animals differ in their sensitivity to allergens, both in the induction phase of asthma as well as in elicitation of the asthma symptoms. Besides examining pulmonary function and inflammation in the lung, this project examines gene expression in the lungs of both young and adult mammals to determine if differences can be identified in the mechanism of asthma depending on age and gender. Molecular differences discovered in different asthma phenotypes may provide information regarding appropriate therapy for the disease depending on the age and gender of the individual. The researchers use the resources of the CGL to assist in the analysis of the gene expression data.

Group Members

Amy Greene, Co-Principal Investigator
Ronald R. Regal, Co-Principal Investigator