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Research Abstracts Online
January 2010 - March 2011

Main TOC

University of Minnesota Duluth
Medical School Duluth
Department of Physiology and Pharmacology

PI: Teresa Rose-Hellekant

Molecular Targets of Tamoxifen Breast Cancer Chemoprevention

These researchers are evaluating the precancerous mammary transcriptome in mice that have received the estrogen modulator tamoxifen as a cancer preventive. These mice are genetically engineered to overexpress an oncogene in the mammary gland, undergo tumorigenesis with a high degree of repeatability, and demonstrate a significant delay in tumor latency and multiplicity when estrogen signaling is abrogated during the precancerous period. The overall goal is to identify a gene expression signature that is predictive of tamoxifen sensitivity and thereby uncover genes that are targets of estrogen receptor signaling.

Group Members

Amy Greene, Mercer Hospital, Savannah, Georgia
Olga Zhdankin, Research Associate