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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
College of Biological Sciences
Medical School
Department of Genetics, Cell Biology, and Development

PI: Ann E. Rougvie

Caenorhabditis Genetics Center; Temporal Control of Development in Caenorhabditis elegans

These researchers are using MSI resources for two projects involving the nematode Caenorhabditis elegans, a developmentally simple organism. The goal of the first is to collect, maintain, and distribute nematode strains, primarily C. elegans, to the international scientific community. MSI resources are used to house servers for the Caenorhabditis Genetics Center, allowing users to access and search database information as well as providing an interface that allows users to securing place orders.

In the second project, the researchers are studying C. elegans to understand how cells execute specific events at precise times during development. Specifically, they dissect the timing mechanism that restricts the differentiation of hypodermal cells to a time late in the life of the worm, the transition from the larval to adult form. The approach is to identify mutations that cause this event to occur at the wrong time during development, and then to study the genes defined by these mutations. These genes are referred to as "heterochronic” genes because their mutation alters the relative timing and sequence of many developmental events in the animal. The long-term goal of this research is to determine how developmental timing mechanisms are integrated with the spatial and sexual cues required for proper development of metazoans.

Group Members

Aric Daul, Staff
Tamar Resnick, Staff
Bradley Scutvick, Staff
Theresa Stiernagle, Staff