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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
Medical School
Department of Surgery

PI: Sabita Roy

Chronic Morphine Modulates Fc-gamma Receptor Mediated Phagocytosis via cAMP Mechanism

Morphine has been known to inhibit innate immunity. Several studies show that morphine inhibits phagocytosis, but the mechanistic of this inhibition remains to be explained. This group’s results showed that chronic morphine treatment, in vitro and in vivo, modulates Fc-gamma receptor-mediated phagocytosis in murine macrophages. The group used the BMSDL and the SDVL to further elucidate the mechanism of morphine-induced decrease of bacterial internalization and its role in modulation of key initiators of phagocytosis.

Group Member

Jana Ninkovic, Graduate Student