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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
Medical School
Department of Microbiology

PI: Leslie A. Schiff

Cellular Entry of Reovirus Virions and ISVPs

These researchers are working to determine the mechanisms by which reovirus virions and infectious subviral particles (ISVPs) enter host cells. While reovirus is normally non-pathogenic, it is currently undergoing clinical trials as a cancer therapeutic. Existing data has shown that clathrin-dependent endocytosis is important for the uptake of reovirus virions, but it is unknown how ISVPs, which may be formed in the tumor microenvironment, enter the cell. Using several approaches, the researchers are characterizing the entry pathway of the particles. Several imaging techniques, including widefield microscopy and deconvolution, form a basis of this work.

Group Members

Amelia K. Haj, Undergraduate Student
Linse B. Lahti, Staff
Wade L. Schulz, Graduate Student