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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
Medical School
Department of Pediatrics

PI: Scott B. Selleck

TOR Signaling and Neural Development in Drosophila

These researchers investigated the role of the Target of Rapamycin (TOR) signaling system in neural development and behavior, using Drosophila as their model system.  Disruption of TOR signaling in humans produces benign tumors as well as a wide range of neurodevelopmental and behavioral deficits, a syndrome known as tuberous sclerosis complex. The researchers explored the function of principal inputs to TOR signaling as well as known downstream affectors in controlling synapse development and function, axon guidance and behavior. Experiments included studies of differential gene expression governed by TOR activity in the group’s Drosophila model of tuberous sclerosis.

Group Members

Bridget K. Campion, Graduate Student
Jae Eun Choi, Undergraduate Student