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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
College of Veterinary Medicine
Department of Veterinary Biomedical Sciences

PI: Pamela J. Skinner

Prion-Disease-Induced Altered Gene Expression in Spleen and Brain Prior to Clinical Symptoms

Prion diseases are fatal neurodegenerative disorders that affect animals and humans. There is a need to gain understanding of prion disease pathogenesis and to develop diagnostic assays to detect prion diseases prior to the onset of clinical symptoms. The goal of this study was to identify genes that show altered expression early in the disease process in the spleen and brain of prion disease-infected mice.

Group Members

J.J. Hong, Graduate Student
Hyeon Kim, Staff
Nikki Kinzel, Staff
Jake Kurth, Undergraduate Student
Barb Pinch, Staff