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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
College of Pharmacy
Department of Experimental and Clinical Pharmacology

PI: Robert J. Straka

The Impact of Genetic Determinants of Fenofibrate's Pharmacokinetics on Lipid Response

The goal of this project was to identify the role of drug-metabolizing genes in determining response to a lipid-lowering drug (fenofibrate). Dyslipidemia is a major risk factor contributing to cardiovascular (CV) disease morbidity and mortality. In spite of optimal low-density lipoprotein lowering with statins, CV risk remains high for patients with elevated triglyceride/low high-density lipoprotein profiles. Because of substantial variability in response to drugs, not all patients benefit equally from lipid-lowering drug therapy. Identifying sources of variability in response to lipid lowering drugs would aid clinicians seeking to optimize drug selection for these patients.

Group Members

Azher Arafah, Graduate Student
Chris Boreen, Undergraduate Student
Brittany Hogan, Undergraduate Student
Preethi Krishnan, Undergraduate Student
Dianna Seng, Undergraduate Student