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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
College of Biological Sciences
Medical School
Department of Biochemistry, Molecular Biology, and Biophysics

PI: Howard C. Towle

Nutritional and Hormonal Control of Hepatic Genes

The long-range goal of this project is to understand the molecular mechanisms by which the transcription factor ChREBP mediates glucose control of liver gene transcription. Glucose metabolism initiates an important intracellular signaling pathway leading to increased expression of genes encoding lipogenic enzymes in the liver. In so doing, glucose functions together with insulin to regulate the storage of excess dietary carbohydrate in the form of triglyceride. These researchers have previously used DNA microarray analysis to identify targets genes of ChREBP. This allowed them to demonstrate the physiological role of this factor in controlling lipogenesis. Ongoing efforts are directed at exploring the mechanism by which glucose influences activity of ChREBP. This work involves analyzing sequences of ChREBP and its target genes and access to the MacVector program is highly useful for this purpose. This work on metabolic regulation has implications for the control of obesity and type 2 diabetes in the population.

Group Members

Michael Davies, Graduate Student
Brennon O’Callaghan, Staff