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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
College of Biological Sciences
Medical School
Department of Biochemistry, Molecular Biology, and Biophysics

PI: Gianluigi Veglia, Associate Fellow

Structural Modeling and Molecular Dynamics Simulations of Membrane Protein Complexes

Membrane proteins play vital roles in many cellular processes such as cell fusion, signal transduction, ion translocation, and homeostasis, among others. To link structure to function, it is necessary to understand membrane protein dynamics within their native environment. These researchers use NMR spectroscopy to study membrane protein complexes in lipid environments. However, NMR does not provide a comprehensive (atomic) view of the interactions of these proteins with the lipid membranes. The researchers use MSI resources to develop new computational approaches to model membrane protein structures and to study their dynamics in explicit lipid membranes.

Group Members

Fa-An Chao, Graduate Student
Kim Ha, Graduate Student
Larry Masterson, Graduate Student
Kaustubh Rajeev Mote, Graduate Student
Lei Shi, Graduate Student
Meng Shi, Undergraduate Student
Nathan Traaseth, Graduate Student
Yi Z. Wang, Undergraduate Student