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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
Medical School
Department of Pediatrics

PI: Michael R. Verneris

HSC-Derived LTi-Like Cells to Accelerate Immune Reconstitution

Recent studies show that LTi-like cells are hematopoietic cells that are directly involved in the organogenesis and maintenance of secondary lymphoid tissue (SLT). SLT is frequently injured during viral infection, chemotherapy, and irradiation therapy. The ability to regenerate SLT may be critical to immunological reconstitution after chemotherapy and bone marrow transplantation. LTi cells have the potential to perform these activities, but at present there is no way to isolate these cells from healthy donors. The goal of this project is to devise methods to generate LTi-like cells from hematopoietic stem cells.