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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
College of Biological Sciences
Medical School
Department of Genetics, Cell Biology, and Development

PI: Daniel F. Voytas

Strategies for Targeted Mutagenesis

The Voytas lab develops methods to make precise modifications to plant and animal genomes. One approach involves the use to transposable elements, which recognize distinct chromosomal sites. Another approach uses engineered nucleases that recognize and cleave specific chromosomal sequences. Repair of the broken chromosome can create mutations. Alternatively, specific DNA sequence modifications can be incorporated at the break site. The targeted mutagenesis approaches being developed by these researchers can be used to engineer the genomes of diverse plant and animal species.

Group Members

Joshua Baller, Graduate Student
Yiping Qi, Research Associate