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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
College of Biological Sciences
Medical School
Department of Biochemistry, Molecular Biology, and Biophysics

PI: Kylie J. Walters, Associate Fellow

Studies of Regulated Protein Degradation

These researchers study how the ubiquitin-proteasome pathway targets protein substrates for degradation. Central to this process is the ubiquitin recognition family of proteins, which include Rpn13, S5a, and the UBL-UBA family of proteins. The researchers use NMR and MSI resources to determine the three-dimensional structure of these key ubiquitin receptors alone as well as complexed with ubiquitin and other proteins. They also study how substrate proteins are identified in cells and why this process sometimes goes awry.

Group Members

Xiang Chen, Research Associate
Aaron Ehlinger, Graduate Student
Yong-A Hong, Staff
Fen Liu, Graduate Student
Leah Randles, Graduate Student
Kimberly Wadsworth, Research Associate
Naixia Zhang, Research Associate