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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
Academic Health Center
Masonic Cancer Center

PI: Douglas Yee

Profiling the Role of IRS Proteins in Breast Cancer Through Gene Expression Analysis

The insulin-like growth factor (IGF) pathway mediates aberrant function during the initiation and progression of primary tumors and secondary metastases in cancer. As a result, a host of tyrosine kinase inhibitors and monoclonal antibodies directed against the type 1 IGF receptor (IGF-1R) have entered clinical trials with early positive results. However, no predictive biomarkers have yet emerged from these initial studies. These researchers investigated the possibility that expanding IGF biomarkers beyond IGF-1R alone may identify the most appropriate candidates for anti-IGF therapy. They used the CGL for this project.

Group Member

Mark Becker, Graduate Student