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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
College of Food, Agricultural, and Natural Resource Sciences
Department of Plant Pathology

PI: Nevin D. Young, Associate Fellow

A Medicago truncatula HapMap as a Platform for Exploring the Genetics of Symbiosis

This project will use whole-genome association mapping (WGAM) to create a Medicago HapMap as a framework for discovering the genes and gene-systems that play a role in the contemporary evolution of symbiosis. In brief, approximately 400 diverse Medicago lines will be resequenced using next generation sequencing technology in order to search for single nucleotide polymorphisms (SNPs), gene copy number variation, and insertion/deletion polymorphisms among the different Medicago lines. This massive database of SNPs and sequence variants will enable the discovery of genome segments with shared ancestry (haplotypes), which can then be used for statistical and data-mining techniques in the discovery of genotype/phenotype relationships involved in symbiosis. Because of the exceedingly high level of variant density discovery made possible through next generation sequencing, this WGAM strategy will approach single gene level resolution.

Group Members

Michael Sadowsky, Co-Principal Investigator
Peter Tiffin, Co-Principal Investigator
Roman Briskine, Staff
Roxanne Denny, Staff
Tim Paape, Research Associate
Charlie Paule, Research Associate
Kevin Silverstein, Research Associate
Peng Zhou, Graduate Student