Research Abstracts Online
January 2010 - March 2011
University of Minnesota Twin Cities
PI: Bevan Yueh
Swallowing After Treatment of Advanced Laryngeal Cancer
For selected subgroups of patients with advanced laryngeal cancer, there is strong evidence that chemoradiation leads to successful laryngeal preservation without sacrificing survival. Yet high stricture and aspiration rates in these patients suggest that this assumption does not necessarily hold in many patients. The goal of this study is to compare the impact of primary chemoradiation versus surgery on swallowing, in patients with advanced larynx cancers that would require total laryngectomy for cure. The researchers are performing a prospective, observational, multi-institutional cohort study. The specific aims are to: determine whether total laryngectomy leads to better self-reported swallowing; explore the relative impact of surgery versus chemoradiation on secondary outcomes such as objective measures of speech and swallowing, self-reported health status, head-and-neck-specific function, and speech; and identify pre-treatment variables that predispose to poor swallowing function after treatment.
Wenjun Kang, Graduate Student