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BradeenJM

Research Abstracts Online
January - December 2011

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University of Minnesota Twin Cities
College of Food, Agricultural, and Natural Resource Sciences
Department of Plant Pathology

PI: James M. Bradeen

Functional and Structural Geonomics of Potato Disease Resistance

Genetic control of potato diseases can reduce grower and environmental costs. The genus Solanum encompasses ~1500 species, including potato, tomato, and eggplant. This research aims to identify, characterize, and access disease resistance genes found in Solanum species and has two foci. First, the researchers are developing a series of physical genomics resources for selected Solanum species. These resources include BAC-based physical maps, genetic linkage maps, and catalogs of candidate disease resistance genes. The group’s efforts are elucidating the evolutionary impact speciation events have had on genome structures and disease resistance gene fates in the genus Solanum. Their findings are being translated into comparative genomics approaches for rapid and efficient cross-species gene mapping and cloning. Second, the researchers are studying how plants modulate defense responses throughout development and in different organs. These efforts pair phenotypic assays with next generation sequencing transcriptome analyses. This research demonstrates that disease resistance phenotypes change with plant physiological age independent of disease resistance gene transcript levels. Additionally, the research has uncovered similarities and differences in the ways in which different plant organs respond to a common pathogen. The research results are being translated into disease management recommendations for production agriculture.

Group Members

Andrea E. Clark, Graduate Student
Matthew D. Clark, Graduate Student
Liangliang Gao, Graduate Student
Massimo Iorizzo, Graduate Student
Harpartap Mann, Research Associate
Steven McKay, Graduate Student
Noah Rosenzweig, Research Associate
Carl Schmitz, Graduate Student
Adriana Telias, Graduate Student