Research Abstracts Online
January - December 2011
University of Minnesota Twin Cities
PI: Frank H. Burton
This project involves performing three-dimensional modeling, in Maestro, of theoretical non-replicative RNA oligonucleotide reproduction complexes. These complexes are selected on the basis of their theoretical structural capacity to facilitate or catalyze random oligonucleotide polymerization and non-random template reproduction, on the basis of their ability to form crystalline lattices with predictable three-dimensional structures, and on the basis of the Macromodel-calculated minimal energy states of their potential alternate conformations based on phosphate-backbone bond rotation. Data obtained from these three-dimensional computer simulations will later guide the chemical synthesis and annealing of real-world oligonucleotide complexes for test-tube confirmation of their predicted catalytic capacity and crystallographic confirmation of their predicted three-dimensional structures.
Max Freier, Collaborator