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Research Abstracts Online
January - December 2011

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University of Minnesota Twin Cities
College of Pharmacy
Department of Medicinal Chemistry

PI: Carrie Haskell-Luevano

Drug Design for GPCRs

This group’s research focuses around the understanding of how the neuroendocrine melanocortin system is involved with the regulation of food intake, energy homeostasis, obesity, diabetes, and other physiological functions and associated disease states. By the use of drug design approaches and computer molecular modeling involving both ligands and the corresponding G-protein Coupled Receptors (GPCRs), the researchers aim to probe ligand-receptor interactions for different agonist versus antagonist pharmacological responses as well as for receptor subtype selectivity. These data are then incorporated into an iterative strategy with the overall goal of designing molecules that reduce food intake via a satiety mechanism or, conversely, increase food intake.

Group Member

Anamika Singh, Research Associate