Research Abstracts Online
January - December 2011
University of Minnesota Twin Cities
Department of Surgery
PI: Paul A. Iaizzo
Modeling Phrenic Nerve Stimulation From Cardiac Resynchronization Therapy
Cardiac resynchronization therapy has been shown to successfully treat cardiac dyssynchrony. Phrenic nerve stimulation is a potential undesired side effect of cardiac resynchronization therapy. These researchers are comparing in situ swine cardiac and phrenic nerve pacing thresholds from various pacing positions within the cardiac veins with electric fields simulated by a computational model of left venous pacing. Once the model is validated, they will use human inputs to determine the optimal left-sided lead electrode spacing that will stimulate the myocardium and not the phrenic nerve. MSI resources are used to generate the electric field model in the cardiac veins and surrounding tissue using Maxwell 3D modeling software.
Julianne H. Eggum, Graduate Student