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Research Abstracts Online
January - December 2011

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University of Minnesota Twin Cities
College of Biological Sciences
Medical School
Department of Biochemistry, Molecular Biology, and Biophysics

PI: Romas Kazlauskas, Associate Fellow

How Similar Enzymes Catalyze Different Reactions

Enzymes with similar structures can catalyze different chemical reactions. These enzymes differ by many amino acids, typically about 30% or 100 amino acids. Some of these amino acids contribute to the differences in chemical reactions, but others do not. These researchers are experimentally identifying which amino acids are important and using MSI resources to model these reactions. The modeling provides hypotheses for the role of different amino acids.

Group Members

Kathleen Burnell, Undergraduate Student
Yun Jiang, Graduate Student
Graig Alan Legatt, Graduate Student
Ryo Nasuno, Collaborator
David Nedrud, Undergraduate Student
Tyler Yin, Graduate Student
Zhi-Jun Zhang, Graduate Student