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Research Abstracts Online
January - December 2011

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University of Minnesota Twin Cities
College of Pharmacy
Department of Experimental and Clinical Pharmacology

PI: Vishal Lamba

Regulation of Drug Metabolizing Enzyme and Transporter Expression

This research focuses on the study of transcriptional networks regulating expression of drug response (ADME) genes for identifying key regulatory factors/genetic polymorphisms contributing to the inter-individual variability in drug disposition and metabolism followed by translational studies in relevant patient populations (such as renal transplant patients treated with calcineurin immunosuppressants) to estimate their predictive significance towards therapeutic efficacy and toxicity. This research includes components of computational biology, human genetics/genomics, and drug metabolism and utilizes pathway-based approaches to advance the understanding of the role of gender and pharmacogenomics in drug response variability and/or drug-related adverse events. The project uses the latest bioinformatic and lab-based pharmacogenetic approaches (comparative genomics, gene expression profiling, allelic imbalance estimation, etc.) to answer specific, clinically relevant research questions.

Group Members

Kinjal Sanghavi, Undergraduate Student