University of Minnesota
University Relations

Minnesota Supercomputing Institute

Log out of MyMSI

Research Abstracts Online
January - December 2011

Main TOC ...... Next Abstract

University of Minnesota Twin Cities
Medical School
Department of Pharmacology

PI: Jonathan S. Marchant

Functional Architecture of IP3-Evoked Local Ca2+ Signals

This study aims to combine experimental data with high-resolution stochastic modeling to demonstrate the viability of a structural model for the clustered organization of IP3 receptors in the endoplasmic reticulum. Recent electrophysiological data has implied that IP3 receptors form a tightly clustered Ca2+channel unit ("contact" model) within intracellular membranes. However, a more loosely corralled architecture of IP3Rs ("corral" model) may also support local Ca2+ release channel activity, and indeed has more congruence with optical imaging data collected from native endoplasmic reticulum membranes. The message of this research is that both alternatives need to be considered by experimentalists in the context of recent debate over IP3R clustering.

Group Member

John D. Chan, Graduate Student