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Research Abstracts Online
January - December 2011

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University of Minnesota Twin Cities
College of Biological Sciences
Medical School
Department of Biochemistry, Molecular Biology, and Biophysics

PI: Hiroshi Matsuo, Associate Fellow

Structural Studies of APOBEC Proteins

Human APOBEC3G (A3G) proteins are capable of altering the HIV genome by deaminating cDNA cytosines to uracils. This activity can genetically inactivate the virus. As a counter-defense mechanism, HIV promotes the ubiquitin-mediated protein degradation of the A3 proteins. Degradation requires that the A3 proteins interact with the HIV virion infectivity factor (Vif) protein. The major objectives of this research are to obtain a structural understanding of the DNA cytosine deaminase activity of A3 proteins and of the A3-Vif interaction.

Group Members

Kuan-ming Chen, Graduate Student
Matthew H. Devany, Graduate Student
Salah James El Haddi, Undergraduate Student
Elena Harjes, Research Associate
Aya Kitamura, Research Associate
Takahide Kono, Research Associate
William C. Solomon, Graduate Student