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Research Abstracts Online
January - December 2011

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University of Minnesota Twin Cities
Medical School
Department of Laboratory Medicine and Pathology

PI: James B. McCarthy

Tumor Microenvironment Control of Malignant Progression

The tumor microenvironment plays a critical role in the malignant progression of tumors. The work in this laboratory focuses on how tumor cell interactions of the elements of the tumor microenvironment impacts on tumor growth, survival, metastasis and resistance to therapies. Tumors express specific cell surface receptors that can stimulate oncogenic signal transduction in tumors and understanding the molecular basis of these interactions and signaling pathways could lead to new therapies that that could help to control malignant progression and improve therapeutic responsiveness. MSI resources will help in the processing of complex expression array data in malignant tumors with the goal of identifying networks of signaling pathways that are impacted by expression of specific tumor cell surface receptors for the microenvironment.

Group Members

Jennifer H. Carlson, Graduate Student
Matthew A. Price, Staff
Jianbo Yang, Research Associate