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Research Abstracts Online
January - December 2011

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University of Minnesota Twin Cities
Medical School
Department of Integrative Biology and Physiology

PI: Joseph M. Metzger

Molecular Modeling of the Troponin Complex

Different isoforms of thin filament proteins within the context of the heart result in marked differences in the contractile performance. This group’s research has shown that critical regulatory domains of these proteins are of utmost importance in influencing this function. Through collaboration with Dr. Yuk Sham (Center for Drug Design), these researchers have done molecular dynamics simulations to define the potential interaction interface differences between two different troponin molecules. Further work will be to substitute residues within this interaction domain to characterize the effect on interaction in these simulations. These studies will lead to functional experiments in the future.

Group Members

Joshua Martindale, Research Associate
Brian Thompson, Research Associate
DeWayne Townsend, Faculty Collaborator