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MuellerDL

Research Abstracts Online
January - December 2011

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University of Minnesota Twin Cities
Medical School
Department of Medicine

PI: Daniel L. Mueller

Epigenomics of Clonal Anergy

T cell clonal anergy is an immunological tolerance mechanism that leads to functional unresponsiveness of T cells. These researchers have used gene array technologies to probe mRNA levels and gene promoter histone acetylations in normal and anergic T cells. They use MSI to try to understand statistically important gene signatures and relating them to function pathways using Expressionist and Ingenuity software.

Group Member

Sara Nandiwada, Research Associate