Research Abstracts Online
January - December 2011
University of Minnesota Twin Cities
PI: Daniel L. Mueller
Epigenomics of Clonal Anergy
T cell clonal anergy is an immunological tolerance mechanism that leads to functional unresponsiveness of T cells. These researchers have used gene array technologies to probe mRNA levels and gene promoter histone acetylations in normal and anergic T cells. They use MSI to try to understand statistically important gene signatures and relating them to function pathways using Expressionist and Ingenuity software.
Sara Nandiwada, Research Associate