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Research Abstracts Online
January - December 2011

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University of Minnesota Twin Cities
College of Biological Sciences
Medical School
Department of Genetics, Cell Biology, and Development

PI: Mary E. Porter

Assembly, Targeting, and Regulation of Dynein Motors

Dyneins are microtubule-based motors involved in intracellular transport and flagellar motility. Cilia and flagella play critical roles in human health and disease, and defects in the activities of dynein motors can lead to infertility, chronic respiratory disease, and birth defects. These researchers study genes that regulate the assembly, targeting, and regulation of dynein motors in eukaryotic flagella using the genetic model organism Chlamydomonas. They use the resources of MSI to analyze the nucleotide sequences of flagellar genes and mutations and also to analyze light microscope images of flagellar assembly and motility.

Group Members

Raqual Bower, Staff
Alexandria M. Schauer, Undergraduate Student
Paula Soneral, Department of Chemistry, Crown College, St. Bonifacus, Minnesota
Doug Tritschler, Staff
Kristyn VanderWaal Mills, Graduate Student