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SalomonCE

Research Abstracts Online
January - December 2011

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University of Minnesota Twin Cities
Academic Health Center
Center for Drug Design

PI: Christine E. Salomon

Identification and Structural Characterization of Novel Natural Products

The focus of this research program is the discovery of novel secondary metabolites from terrestrial and marine bacteria and fungi. This group identifies new compounds by using bioassay-guided fractionation to purify biologically active molecules, with an emphasis on activity against drug resistant pathogens and cancer targets. Another area of interest is to identify “cryptic” or silent biosynthetic pathways and to understand how these pathways can be activated to make new natural products. The researchers use DNA sequence analysis software to assist with the construction of reporter bacterial strains used for detecting intermicrobial signaling. They also use NMR software to analyze data and characterize novel natural product structures.

Group Members

Neetha Eduthan, Graduate Student
Chris Gelbmann, Staff
Jon Henrikson, Research Associate
Yudi Rusman, Research Associate