University of Minnesota
University Relations

Minnesota Supercomputing Institute

Log out of MyMSI

Research Abstracts Online
January - December 2011

Main TOC ...... Next Abstract

University of Minnesota Twin Cities
College of Biological Sciences
Medical School
Department of Biochemistry, Molecular Biology, and Biophysics

PI: Claudia Schmidt-Dannert

Fungal Genome Analysis

This group is currently sequencing and annotating the genomes of several fungal species. In one project, they are analyzing the biosynthetic potential of higher fungi (mushrooms and basidiomyctes). Basidiomycetes are known for synthesizing natural products with unusual structures not found in other organisms. Despite their long-standing use in traditional medicine, very little is known about the biosynthesis of their biologically active compounds. Genome sequencing of select fungi allows us to elucidate on a molecular level biosynthetic pathways for natural products. The obtained genetic information then enables us to re-engineer those metabolic routes into heterologous hosts for biochemical characterization and production of bioactive natural products.

Group Members

Sarah Elizabeth Block, Graduate Student
Ethan Johnson, Research Associate
Laura Mazzaferro, Collaborator
Grayson Wawrzyn, Staff