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Research Abstracts Online
January - December 2011

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University of Minnesota Twin Cities
Medical School
Department of Pediatrics

PI: Elsa G. Shapiro

Brain Structure and Function in MPS I, II, III, and VI

The purpose of this study is to better understand the brain pathophysiology that results in cognitive and behavioral abnormality or decline in mucopolysaccharidoses (MPSs).
MPSs are a group of inherited metabolic diseases in which a defective or missing enzyme results in the accumulation of harmful amounts of mucopolysaccharides (complex sugar molecules) in cells and tissues. There are six different types of MPS disorders with varying degrees of severity and a characteristic phenotype. This study includes measures of cognitive ability, attention, memory, and visual-spatial skills as well as acquisition of head MRIs on three Tesla scanners for volumetric analysis and for diffusion tensor imaging. The researchers are now in their third year of the longitudinal study.

Group Members

Alia Ahmed, Research Associate
Victor Kovac, Staff
Igor Nestrasil, Research Associate