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Research Abstracts Online
January - December 2011

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University of Minnesota Twin Cities
College of Veterinary Medicine
Department of Veterinary Population Medicine

PI: Srinand Sreevatsan, Associate Fellow

Mycobacterial Responses in the Host and Disease Modeling

The Sreevatsan lab is characterizing Mycobacterium bovis variants that are expected to aid in elucidation of M. bovis evolution, zoonotic importance, and the allele-pathogenicity trait. In order to identify a trait-allele association among M. bovis isolates, current research focuses on single nucleotide polymorphisms (SNPs) characterization in the genome of M. bovis isolates. Novel SNPs will be identified by sequencing two M. bovis isolates. These researchers use MSI resources to assemble these genomes. In addition to M. bovis genome and SNP characterization, the researchers seek to establish a Mycobacterium avium subspecies paratuberculosis (MAP)-bovine epithelial interactome. Towards this end, several MAP-bovine epithelium RNA samples have been processed for RNA-seq. The researchers are using MSI tools such as Galaxy to analyze and pair host and pathogen transcriptomes.

Group Members

Shin Enomoto, Research Associate
Preethi Haran, Graduate Student
Deepti Joshi, Graduate Student
Abirami Kugadas, Graduate Student
Elise Lamont, Graduate Student
Amanda Oliveira, Graduate Student
Ping Wang, Staff
Manoosak Wongphatcharachai, Visiting Researcher
Jeffry C. Wymer, Graduate Student
My Yang, Staff