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Research Abstracts Online
January - December 2011

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University of Minnesota Twin Cities
Medical School
Department of Medicine

PI: Christine H. Wendt

Biomarkers in Lung Disease

Lung transplantation is an effective therapy for many end stage lung diseases. Despite advances in immunosuppressive therapy, chronic rejection remains a leading cause of morbidity and mortality. While certain markers of inflammation have been identified currently no set of biomarkers predictably identify patients who are at risk of or currently have chronic rejection. It is possible that there are distinct and reproducible sets of protein products within the lung that characterize chronic rejection and can be characterized into a biosignature of rejection. This researcher chose broncho-alveolar lavage fluid as a starting point to identify a biosignaure of rejection since the small airways are the observable site of chronic rejection and are likely to yield a strong signal. The goal of this project is to identify and validate effective biomarkers for eventual use as diagnostic tools for the detection of chronic lung allograft rejection.