Research Abstracts Online
January - December 2011
University of Minnesota Twin Cities
PI: George L. Wilcox
Proteome Changes in Human Epidermis Induced by UVB Irradiation
Long-term exposure to sun (UVB) induces skin cancer, premature skin aging and cutaneous immunosuppression. Comprehensive analysis of UVB-induced changes in the human epidermal proteome may assist in discovery of UVB-induced damage biomarkers. These researchers have examined epidermal proteins after UVB exposure and showed that the UVB altered expression of distinct proteins. The results indicate that during the first 24 hours after being exposed to UVB, human epidermal cells alter the expression of several proteins to protect the skin from oxidative damage and invite neurite extension.
Elhabib Benlhabib, Research Associate