Three-Dimensional Reconstruction of Meniere's Disease and Facial Nerve in Mondini's Dysplasia
MD is the most common diagnosis in patients referred to vertigo clinics, with 2.4 - 7.5 million cases in the USA. MD has a severe adverse impact on quality of life, since the attacks of vertigo are often unpredictable and incapacitating. Endolymphatic hydrops is well established as the histopathologic marker of the disease. A number of studies describe various developmental anomalies involving and surrounding the endolymphafic drainage system. Some of these studies looked at one (or a few) parameters in isolation. Also, some of the abnormalities are best assessed in three dimensions rather than using two-dimensional histology. These researchers are working on a comprehensive and simultaneous assessment of all these possible changes in the same HTB in three dimensions. They also seek correlations between the severity and duration of the disease and the intensity of the pathologic abnormalifies. The data may provide insight into the pathogenesis of hydrops. For example, they will be able to test the hypothesis that a combinafion of subtle developmental anomalies (combination of small volume of e. duct and sac, small internal aperture and reduced pneumatization) may be the best predictor of hydrops. If the hypothesis is supported, it may suggest that such anomalies may gradually lead to dysfunction of the endolymphatic duct, primarily the malabsorption of endolymph, ultimately ending up with MD.