Companion Animal Genetics and Genomics

Abstract: 

Companion Animal Genetics and Genomics

Simple and complex heritable diseases are relatively common in companion animal species due to selected breeding schemes that use common founders and family lines to propagate highly desirable traits. These researchers are using genetic association analyses to begin to identify the genetic loci responsible for a number of heritable disorders in dogs (epilepsy, polyneuropathy, leukomyloencephalpapthy, exercise-induced collapse) and horses (exertional rhabdomyolysis, polysaccharide storage myopathy, alternative gait). Genotypes for Single Nucleotide Polymorphism (SNP) markers across the genome are analyzed for association with the trait in large often-complex populations. Identification of SNPs that associate with the trait in essence maps the gene for the trait to that region where the responsible gene can ultimately be identified. The researchers are then utilizing next-generation DNA sequencing on the Illumina Genome Analyzer to obtain whole genome sequences from dogs and horses to begin to define genetic variants within regions defined by the genome scans as well to define the transcriptome of tissues likely involved in the phenotypes. They use MSI facilities, including the CGL, to perform the association analysis computations to enable them to more efficiently identify the genome segments containing the disease genes, as well as Galaxy to process the whole genome and transcriptome sequence data.

A bibliography of this group’s publications acknowledging MSI is attached.

Group name: 
mickelso
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