Molecular Biology of Cancer
These researchers are using MSI for several projects.
- 8q24 gain in human cancer: Gain or amplification of 8q24 is a prominent mutation in human cancers. MYC, the prominent oncogene in the 8q24 region, has been the usual suspect. These researchers have recently discovered that MYC gained cancers are dependent on an adjacent long non-coding RNA PVT1, leading to the possibility of PVT1 being a surrogate target for MYC in these cancers.
- Role of p53 in cellular senescence: The tumor suppressor p53 plays a critical role in cellular senescence. However, the mechanism underlying cellular senescence is poorly understood. The researchers have generated mouse models with differential dosage of p53 to investigate how p53 contribute to senescence.
- Role of endogenous retroviral elements in cancer: Endogenous retrovirsues (ERV), the remnants of ancient viruses that colonized vertebrate genome, are often found to be upregulated in cancers. The researchers are interested to understand the mechanism by which these ERV elements contribute to human cancer.
- Role of CHD5 in cancer: The researchers had previously identified Chromodomain helicase DNA binding protein (CHD5), a chromatin remodeling gene, as a tumor suppressor. CHD5 located in Hu 1p36.3, a locus frequently deleted in many cancers. They are now investigating the molecular mechanism of tumor suppression by CHD5.
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