Functional Analysis of Low Copy Number Gain of Human 8q24 in Breast Cancer

Abstract: 

Functional Analysis of Low Copy Number Gain of Human 8q24 in Breast Cancer

These researchers hypothesize that low copy number gain of Hu 8q24 is a driver mutation in breast cancer and contributes to poor prognosis by altering the proliferation and differentiated state of mammary epithelial cells in situ. They also hypothesize that mammary transformation requires the cooperation of multiple genes within this chromosomal region. This group's long-term goal is to address whether cancer cells are addicted to this low copy number gain at Hu 8q24, and if so, could this be exploited therapeutically resulting in better management and/or prolonged survival in patients.

Group name: 
bagchia