Biomarkers for Autoimmunity
Investigations by this group are aimed at identifying pathways that are dysregulated in autoimmunity by studying biological samples collected from patients with autoimmune disease. For example, one project seeks to develop a test that can predict disease activity or other clinical outcomes of SLE using a panel of proteins that can be measured in a blood sample. Another project is focused on interferon-inducible serum chemokines, which are among the proteins associated with lupus disease activity and flare, and how they might be contributing to the disease process. This project is exploring the potential role of these chemokines in lupus-associated cardiovascular disease. In addition, this Principal Investigators directs the Human Immunology Biomarkers Core in the Rheumatology Division, which provides infrastructure and support for human biomarker studies related to autoimmunity. The Biomarkers Core manages a biorepository that houses > 64,000 samples from > 5,000 subjects enrolled in these studies, along with the associated study databases.
Return to this PI's main page.