A Hemodynamic Simulation Model Assisting Liver Embolotherapy Based on Anatomical Reconstruction of Hepatic Microvasculature
The objective of this project is to develop a hemodynamic blood flow simulation model for normal and cancerous hepatic microvasculature. The model will be used to aid embolotherapy in treating hepatocelluar carcinoma (HCC). HCC is the primary malignant cancer of liver, for which most patients need nonsurgical therapies. As the cancer is often resistant to chemotherapy, arterial embolization is the most used palliative treatment. Hemodynamic flow simulation can be conducted with a physiologically correct, digitally constructed microvascular network. As the model needs to know down-stream resistance, anatomical reconstruction has to include micro-vessels connecting to capillary bed. These researchers are developing a new approach using modern imaging modalities such as CT and Micro-CT, as those devices can quickly generate 3D reconstructions. However, with a fixed detector size, larger field of view yields lower resolution. Clinical CT images cannot be used to measure micro-vessels, while Micro-CT requires many more acquisitions on smaller sized object. A resolution-adaptable 3D image registration has been developed to stitch up images with different resolutions and orientations. MSI software, i.e. FLUENT, CFX, is used to prove that the model can be used on blood flow dynamic simulation.