Immune Reconstitution Syndrome in HIV Infected Persons; GU-Rich Element-Mediated mRNA Decay in Cellular Activation, Malignancy, and Viral Ocogenesis
These researchers are involved in two projects using MSI. In the first, the researchers analyze microarrays to determine if HIV-infected Ugandan patients who develop CM IRIS (HIV Immune Reconstitution Inflammatory Syndrome manifested as cryptococcal meningitis) express biomarkers in their peripheral blood and spinal fluid that can be used to diagnose IRIS or predict which patients are at risk of IRIS.
Ongoing research for the second project focuses on several aspects of posttranscriptional gene expression regulation by GU-rich element (GRE): genome-wide stabilization of GU-rich containing RNA transcripts in malignancy; the effect of viral infection on the posttranscriptional regulation of GRE-containing transcripts; utilization of GU-rich element by cell through alternative cleavage and polyadenylation; and the role for noncoding RNAs that bind to GRE, in T cell activation and function.
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