Integrated Genomic and Proteomic Analyses of Ovarian Cancer for Biomarker Discovery

Abstract: 

Integrated Genomic and Proteomic Analyses of Ovarian Cancer for Biomarker Discovery

Molecular characterization of ovarian cancer has generated large volumes of genomic data through comprehensive and coordinated efforts such as the Cancer Genome Atlas (TCGA) Project and identified associated genomic alterations. However, the mechanism by which altered genes singly or cooperatively transform cells remains poorly understood. By proteomic determination of proteins in cancer tissues, and integrated genomic and proteomic analyses, this project will (a) define a functional cancer proteome that derives from alterations in cancer genomes, (b) identify proteins that are related to genetic mutations, and (c) select and prioritize cancer-related proteins for potential targets as candidate biomarkers for improve ovarian cancer early detection, prognosis, and prediction of treatment outcome.

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