Lipocalin 2 in Inflammation and Metabolic Control
Adipose tissue plays a central role in body weight homeostasis, inflammation, and insulin resistance via regulating lipid metabolism and releasing a range of adipokines/cytokines. However, which adipokine(s) mediate this linkage and the molecular mechanisms of obesity and insulin resistance are poorly understood. The objective of this project is to investigate the role of lipocalin 2 (LCN2) in diet-induced insulin resistance and metabolic homeostasis. The project will measure the development of obesity and insulin resistence in mice under various nutritional states, such as fasting, high-fat diet, and cold stimulation; assess glucose/lipid metabolism in liver, adipose and muscle tissue of lcn2 null mice and lcn2 transgenic mice; and investigate the signaling pathways associated with lipid metabolism, such as retinoic acid pathway, in order to determine the molecular basis for LCN2-mediated homeostasis. The results of this study will increase understanding of the development of obesity and insulin resistence, and provide a potential pharmaceutical target for improving lipid metabolism.