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mitochondrial DNA drug resistance cancer
Mitochondrial DNA and Drug Resistance in Cancer
The purpose of this project is to examine mitochondrial DNA sequence variants in models of drug sensitive and resistant human cancers. The hypothesis is that the abundance of mitochondrial DNA and the abundance of specific sequence variants are predictive of cancer patients’ response to chemotherapy and molecularly targeted therapies. If this hypothesis is correct, mitochondrial biomarkers could be used to design rational cancer treatments tailored to the metabolism of each patient's tumor.