Oligonucleotide Abiogenesis

Abstract: 

Oligonucleotide Abiogenesis

The purpose of this project is to perform 3D stereoscopic modeling, in Maestro, of theoretical non-replicative oligonucleotide reproduction complexes, selected by their ability to facilitate or catalyze random oligonucleotide polymerization and non-random template reproduction, and on the basis of Macromodel-calculated energy states of their phosphate-backbone bond rotational conformations, melting  temperatures, and extents of cationic Wachtershauser-plane attraction. The researchers are using MSI's BSCL facilities for this project. Data obtained from these 3D computer simulations are guiding the chemical synthesis and annealing of real-world oligonucleotide complexes for test-tube confirmation of their predicted binding and catalytic capacity and for crystallographic and/or atomic force microscopic confirmation of their predicted 3D structures.

Return to this PI's main page.

 

 

Group name: 
burtonfh