Protein Structure Discovered

Assistant Professor Hiroshi Matsuo (Department of Biochemistry, Molecular Biology, and Biophysics) has published the structure of the deaminase domain of the APOBECC3G protein in the March 6, 2008 issue of Nature (see K.-M. Chen et al.). The protein is capable of altering the HIV genome by deaminating cNDA cytosines to uracils. This activity can genetically inactive the virus.