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Studies of vitamin A signaling pathways
Studies of Vitamin A Signaling Pathways
This project investigates signaling pathways of vitamin A, including the action via nuclear receptors/coregulators and cytoppasmic modulators. The studies utilize various model systems, including both in vivo genetically modified mouse models and in vitro reconstituted systems that will answer how there regulatory molecules work in concert to modulated the activities of retinoic acid and other dietary components including fat. Signaling pathways will be dissected on the gene level, as well as single molecular level.