Synthesis of Biologically Active Molecules
This group's research interests are focused on the development of new strategies and reagents/catalysts for facilitating the synthesis of biologically active molecules. One family of molecules of particular interest is the hasubanan (HB) alkaloids. These compounds have the potential to serve as lead compounds for the next-generation of opioid receptor ligands. The group is also actively engaged in the design, synthesis, and implementation of chiral aryl iodide catalysts. These catalysts will be used in several different reaction types, including enantioselective oxidative dearomatizations and oxidative transformations of olefins. MSI resources are primarily used to assist in the computer-aided design of new HB alkaloid derivatives and will be used to design future catalysts. Because the transformations involve highly unstable and short-lived intermediates, the computational resources also prove invaluable for studying the mechanism of these transformations.
A bibliography of this group’s publications acknowledging MSI is attached.