Use of NGS in TB Drug Discovery
These researchers are using next-generation sequencing (NGS) to identify novel genetically encoded anti-tuberculosis small molecules and separately to identify polymorphism that are associated with resistance to currently used TB drugs. Using this approach, they have recently identified novel resistance alleles for the drug para-aminosalicylic acid. They are also preparing to use NGS for high-throughput genetic approaches in novel target identification.
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