Alessandro Bartolomucci

Integrative Biology/Physiology
Medical School
Twin Cities
Project Title: 
Functional Proteomics of Aging, Structure-Function Relationship of Biologically Active Peptides and Their Cognate Receptors

This laboratory is primarily interested in the autonomic and neuroendocrine regulation of metabolic functions and their imbalance in pathological conditions relevant for obesity, stress, and aging. They have developed a unique integrative approach to investigate the molecular physiology of obesity and chronic stress-related disease which combines behavioral and genetic models, and metabolic, neuroendocrine, and imaging techniques in living animals as well as sophisticated molecular and structural biology analyses of neuropeptides.

There are three major research topics:

  • The functional role of Vgf-derived peptides in obesity and metabolism and their development as innovative drug targets for obesity-related disease
  • The mechanism(s) of stress-induced cardio-metabolic metabolic disease
  • The impact of chronic stress on aging and lifespan

Project Investigators

Alessandro Bartolomucci
Carey Lyons
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